| 新型多氧取代环己烯酮的合成 |
| |
| 引用本文： | 杨圣伟,陈熙,李振卿,敖桂珍,候丙波.新型多氧取代环己烯酮的合成[J].合成化学,2011,19(5):619-621,625. |
| |
| 作者姓名： | 杨圣伟 陈熙 李振卿 敖桂珍 候丙波 |
| |
| 作者单位： | 苏州大学药学院,江苏苏州,215123 |
| |
| 摘 要： | 以莽草酸为起始原料,经酯化、丙酮叉保护顺式邻二羟基、叔丁基二甲硅烷保护羟基、还原、羟基酯化、脱保护基、保护反式邻二羟基、烯丙醇氧化,脱保护基共9步反应,合成了新型(5R,6S)-3-苯甲酰氧基亚甲基-5,6-二羟基-2-环己烯-1-酮,总产率19.3％,其结构经1H NMR,IR和HR-MS表征.
|
| 关 键 词： | 多氧取代环已烯酮 莽草酸 合成 |
Synthesis of Novel Polyoxygenated Cyclohexenone |
| |
| YANG Sheng-wei,CHEN Xi,LI Zhen-qing,AO Gui-zhen,HOU Bing-bo.Synthesis of Novel Polyoxygenated Cyclohexenone[J].Chinese Journal of Synthetic Chemistry,2011,19(5):619-621,625. |
| |
| Authors: | YANG Sheng-wei CHEN Xi LI Zhen-qing AO Gui-zhen HOU Bing-bo |
| |
| Institution: | YANG Sheng-wei,CHEN Xi,LI Zhen-qing,AO Gui-zhen,HOU Bing-bo(College of Pharmaceutical Science,Soochow University,Suzhou 215123,China) |
| |
| Abstract: | A novel(5R,6S)-3-benzoyloxymethylen-5,6-dihydroxyl-2-cyclohexen-1-one in overall yield 19.3% was synthesized from shikimic acid by a nine-step reaction of esterification,hydroxyl protection,reduction,esteriferication,de-protection,oxidation of allyl alcohol and so on.The structure was characterized by 1H NMR,IR and HR-MS. |
| |
| Keywords: | polyoxygenated cyclohexenone shikimic acid synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
