| 合成金鸡纳生物碱衍生物的简便方法 |
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| 引用本文： | 南鹏娟,陈晶,孙晓莉.合成金鸡纳生物碱衍生物的简便方法[J].合成化学,2011,19(5):667-670. |
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| 作者姓名： | 南鹏娟 陈晶 孙晓莉 |
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| 作者单位： | 1. 陕西师范大学化学与材料学院陕西西安710062
2. 第四军医大学化学系,陕西西安,710062 |
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| 基金项目： | 国家自然科学基金资助项目(20973105) |
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| 摘 要： | 以CaH2为缚酸剂,DMF为溶剂,金鸡纳生物碱通过3,6-二氯哒嗪或1,4-二氯-2,3-二氮杂萘桥连,高产率地合成了用作手性配体的13个金鸡纳生物碱衍生物,其结构经NMR确证.
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| 关 键 词： | 金鸡纳生物碱 哒嗪 二氮杂萘 手性配体 缚酸剂 合成 |
An Easy Method of Synthesizing Cinchona Alkaloid Derivatives |
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| NAN Peng-juan,CHEN Jing,SUN Xiao-li.An Easy Method of Synthesizing Cinchona Alkaloid Derivatives[J].Chinese Journal of Synthetic Chemistry,2011,19(5):667-670. |
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| Authors: | NAN Peng-juan CHEN Jing SUN Xiao-li |
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| Institution: | NAN Peng-juan1,CHEN Jing1,SUN Xiao-li2(1.School of Chemistry and Materials Science,Shaanxi Normal University,Xi'an 710062,China,2.Department of Chemistry,Fourth Military Medical University,China) |
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| Abstract: | Thirteen cinchona alkaloid derivatives as chiral ligand were synthesized from cinchona alkaloid using 3,6-dichloro-pyridazine or 1,4-dichloro-2,3-phthalazone as bridged reagent in the presence of CaH_2 in DMF under mild condition.The structures were confirmed by NMR. |
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| Keywords: | cinchona alkaloid pyridazine phthalazone chiral ligand acid acceptor synthesis |
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