| (S)-(4-溴-2-甲苯)(3-甲基吗啉)甲酮的合成 |
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| 引用本文： | 张光辉.(S)-(4-溴-2-甲苯)(3-甲基吗啉)甲酮的合成[J].合成化学,2017,25(6). |
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| 作者姓名： | 张光辉 |
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| 作者单位： | 陕西中医药大学药学院,陕西咸阳,712046 |
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| 基金项目： | 陕西中医药大学青年基金资助项目 |
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| 摘 要： | 以(S)-2-氨基丙醇和氯乙酰氯为起始原料,经酰化和环合反应制得(S)-5-甲基吗啉-3-酮(4);4经还原制得(S)-3-甲基吗啉(5);5与4-溴-2-甲基苯甲酸酰化缩合合成了(S)-(4-溴2-甲基苯基)(3-甲基吗啉)-甲酮,总收率57%,其结构经~1H NMR和~(13)C NMR确证。
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| 关 键 词： | (S)-2-氨基丙醇 氯乙酰氯 (S)-(4-溴2-甲基苯基)(3-甲基吗啉)-甲酮 药物合成 |
Synthesis of (S)-(4-bromo-2-Methylphenyl) (3-Methylmor pholino) Methanone |
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| ZHANG Guang-hui.Synthesis of (S)-(4-bromo-2-Methylphenyl) (3-Methylmor pholino) Methanone[J].Chinese Journal of Synthetic Chemistry,2017,25(6). |
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| Authors: | ZHANG Guang-hui |
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| Abstract: | (S)-5-methylmorpholin-3-one(4) was obtained by the reaction of acylation and cyclization,using (S)-amino-1-propanol and chloroacetyl chloride as the starting materials.(S)-3-methylmorpho-line (5) was synthesized by reduction of 4.(S)-(4-bromo-2-methylphenyl) (3-methylmorpholino)methanone was synthesized by condensation reaction of 5 with (S)-3-methylmorpholine and 4-bromo-2-methylbenzoic acid,the total yield was 57％.The structure was confirmed by 1H NMR and 13C NMR. |
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| Keywords: | (S)-amino-1-propanol chloroacetyl chloride (S)-(4-bromo-2-methylphenyl) (3-methyl-morpholino) methanone drug synthesis |
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