| 蒙脱土负载碘催化多组分合成咪唑衍生物 |
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| 引用本文： | 尹晓刚,王琳琳,杜莹,龚维,陈卓.蒙脱土负载碘催化多组分合成咪唑衍生物[J].合成化学,2017,25(8). |
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| 作者姓名： | 尹晓刚 王琳琳 杜莹 龚维 陈卓 |
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| 作者单位： | 贵州师范大学 化学与材料科学学院 贵州省功能材料化学重点实验室,贵州 贵阳,550001 |
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| 基金项目： | 贵州省科技合作项目，贵州省科技厅科技支撑项目 |
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| 摘 要： | 以苯偶酰(1)、苯甲醛(2a)、苯胺(3)和醋酸铵(4)为原料,蒙脱土负载碘和三乙烯二胺(DABCO)为催化剂,通过多组分法合成了6种1,2,4,5-四芳基-1,3-咪唑衍生物,其结构经1H NMR和IR确证。对反应条件进行了优化。结果表明:在最优反应条件{以10 mol%MMT/I2为催化剂,10 mol%DABCO为碱,正丁醇为溶剂,原料配比rn(1)∶n(2a)∶n(3)∶n(4)]=1.0∶2.0∶2.0∶8.0,于110℃反应16 h}下,产率最高为91.5%。
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| 关 键 词： | 苯偶酰 苯甲醛 苯胺 蒙脱土负载碘 催化 1 2 4 5-四苯基-1 3-咪唑 合成 |
Synthesis of Imidazole Derivatives Catalyzed by Montmorillonite Supported Iodine |
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| YIN Xiao-gang,WANG Lin-lin,DU Ying,GONG Wei,CHEN Zhuo.Synthesis of Imidazole Derivatives Catalyzed by Montmorillonite Supported Iodine[J].Chinese Journal of Synthetic Chemistry,2017,25(8). |
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| Authors: | YIN Xiao-gang WANG Lin-lin DU Ying GONG Wei CHEN Zhuo |
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| Abstract: | An one pot method of synthesis of 1,2,4,5-tetraphenyl-1,3-imidazole derivatives was developed.Six products were synthesized using benzoyl(1), benzaldehyde(2a), aniline(3) and ammonium acetate(4) as starting material with immobilized montmorillonite/iodine as catalyst.The structures were confirmed by 1H NMR and IR.The reaction conditions were optimized.The results showed that under the optimum reaction conditions{using 10 mol%MMT/I2 as catalyst, 10 mol%DABCO as base additive, and n-butanol as the solvent, raw material molar ratio rn(1)∶n(2a) ∶n(3) ∶n(4)]=1.0 ∶2.0 ∶2.0 ∶8.0, reaction at 110 ℃ for 16 h}, the highest yield was 91.5%. |
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| Keywords: | benzoyl aromatic aldehyde aniline montmorillonite supported iodine catalysis 1 2 4 5-tetraphenyl-1 3-imidazole synthesis |
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