| 新型2-[4-(取代苯甲酰氨基)苯基]苯并噻唑的合成及生物活性 |
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| 引用本文： | 徐鉴,孙幼红,马钰峰.新型2-[4-(取代苯甲酰氨基)苯基]苯并噻唑的合成及生物活性[J].合成化学,2017,25(5). |
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| 作者姓名： | 徐鉴 孙幼红 马钰峰 |
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| 作者单位： | 南京晓庄学院 环境科学学院,江苏 南京,211171 |
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| 基金项目： | 江苏省大学生实践创新训练计划项目 |
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| 摘 要： | 以2-氨基苯硫酚和对氨基苯甲酸为起始原料,设计并合成了5个新型的苯并噻唑衍生物(4a~4e),其结构经1H NMR,IR,MS(EI)和元素分析表征。采用菌丝生长速率法初步研究了4a~4e的生物活性。结果表明:用药浓度为100 mg·L~(-1)时,4b和4c对西瓜枯萎病菌有一定抑制效果,抑制率分别为47%和43%。
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| 关 键 词： | 2-氨基苯硫酚 苯并噻唑 合成 生物活性 |
Synthesis and Biological Activities of Novel 2-[4-(Substituted benzamido)phenyl]benzothiazoles |
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| XU Jian,SUN You-hong,MA Yu-feng.Synthesis and Biological Activities of Novel 2-[4-(Substituted benzamido)phenyl]benzothiazoles[J].Chinese Journal of Synthetic Chemistry,2017,25(5). |
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| Authors: | XU Jian SUN You-hong MA Yu-feng |
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| Abstract: | Five novel benzothiazole derivatives(4a~4e) were designed and synthesized from 2-aminobenzenethiol and 4-aminobenzoic acid.The structures were characterized by 1H NMR, IR, MS(EI) and elemental analysis.The preliminary bioactivities of 4a~4e were investigated by mycelium growth rate method.The results showed that, to some extent, 4b(47%) and 4e(43%) exhibited fungicidal activities against watermelon fusarium oxysporum with dosage of 100 mg·L-1. |
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| Keywords: | 2-aminobenzenethiol benzothiazole synthesis bioactivity |
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