Microwave Assisted Synthesis of Some Novel Thiopyrano[2,3-b]quinolines as a New Class of Antimicrobial Agent |
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Authors: | B P Nandeshwarappa D B Aruna Kumar M N Kumaraswamy Y S Ravi Kumar H S Bhojya Naik K M Mahadevan |
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Institution: | 1. Department of Studies in Industrial Chemistry , Kuvempu University , Shimoga, Karnataka, India;2. Department of Studies in Chemistry , Kuvempu University , Shimoga, Karnataka, India |
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Abstract: | A series of novel substituted thiopyrano2,3-b]quinolines 4a–e , 5a–e , and 6a–e were prepared from substituted 3-formyl-2-mercapto quinolines 2a–e , on reaction with ethyl acetoacetate, diethyl malonate, and ethyl cyanoacetate 3a–c by microwave irradiation in the presence of piperidine. Synthesized compounds were evaluated for antimicrobial activities. Among the compounds tested, 7-chloro-2-oxo-2H-thiopyrano2,3-b]quinoline-3-carbonitrile 6d and 7-nitro-2-oxo-2H-thiopyrano2,3-b]quinoline-3-carbonitrile 6e were highly active against S. aureus and M. roseus. |
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Keywords: | Antimicrobial agent diethyl malonate ethyl acetoacetate ethyl cyanoacetate microwave irradiation thiopyrano[2 3-b]quinolines |
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