|
|||||
|
|
Synthesis of Phenyl or 4-Nitrophenyl Methyl β-Ketophosphonate Esters |
|
| Authors: | Putta M Reddy Carol Viragh Ildiko M Kovach |
| Institution: | Department of Chemistry , The Catholic University of America , Washington, DC , 20064 , USA |
| Abstract: | Seven new aryl methyl g -ketophosphonate esters were synthesized. The hydrolytic rates of the compounds under physiological conditions were studied. Most of the compounds are effective inhibitors of acetylcholinesterase. The enzyme recovers on the 10-50 h time scale from its adducts with two of the inhibitors. |
| Keywords: | Aryl Alkylphosphonate Esters Ketoalkyl Aryl Phosphonate Esters Reversible Inhibitors Serine Hydrolase Inhibitors |