SYNTHESIS OF SOME 2-[(BENZAZOLE-2-YL)THIO]-DIPHENYLMETHYLACETAMIDE DERIVATIVES AND THEIR ANTIMICROBIAL ACTIVITY |
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| Authors: | G Turan-Zitouni Ü Uçucu A Özdemir P Chevallet Y Tunali |
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| Institution: | 1. Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry , Eskisehir, Turkey;2. Montpellier University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry , Montpellier, France;3. Anadolu University, Faculty of Pharmacy, Department of Microbiology , Eskisehir, Turkey |
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| Abstract: | Some 2-(benzazole-2-yl)thio]diphenylmethylacetamide3pc] derivatives were synthesized by reacting 2-chloroacethylaminodiphenylmethane with benzazole-2-thions. The structure elucidation of the compounds was performed by IR, 1 H NMR, and MS-FAB spectral data. Antimicrobial activity of the compounds was examined. Some of the compounds have shown similar antifungal activities against C. albicans when compared with ketoconazole. It was also observed that some of these compounds have moderate antimicrobial activity when compared with chloramphenicole. |
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| Keywords: | Antimicrobial activity benzimidazole benzothiazole benzoxazole |
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