A Convenient Synthesis of Thiazolidin-2-ones from Thiazolidine-2-thiones: Antibiotic Activity and Revisiting the Mechanism |
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| Authors: | Xiaobing Deng Ning Chen Zhixin Wang Xinyao Li Hongyan Hu Jiaxi Xu |
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| Institution: | 1. State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, Faculty of Science , Beijing University of Chemical Technology , Beijing , P. R. China;2. Department of Laboratory Medicine , The General Hospital of Chinese People's Armed Police Forces , Beijing , P. R. China |
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| Abstract: | Abstract Various substituted thiazolidin-2-ones were synthesized from the corresponding thiazolidine-2-thiones with bromoethanol in ethanol with sodium ethoxide as a base. The optimal reaction conditions and mechanism were reinvestigated in detail. The bioassay indicated that (S)-4-isobutyl and (S)-4-benzylthiazolidin-2-ones show certain inhibitive activities against Candida albicans and Escherichia coli. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT |
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| Keywords: | Bromoethanol mechanism sodium ethoxide thiazolidin-2-one thiazolidine-2-thione |
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