The Utility of Isothiocyanato Thiophenes in the Synthesis of Thieno[2,3-d]pyrimidine Derivatives as Possible Radioprotective and Anticancer Agents |
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| Authors: | M M Ghorab A N Osman E Noaman H I Heiba N H Zaher |
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| Institution: | 1. Department of Drug Radiation Research , National Center for Radiation Research and Technology , Nasr City, Cairo , Egypt;2. Department of Organic Chemistry, Faculty of Pharmacy , Cairo University , Cairo , Egypt;3. Department of Radiation Biology , National Center for Radiation Research and Technology , Nasr City, Cairo , Egypt |
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| Abstract: | The synthesis of novel thioureido derivatives 3, 8, and 10; biscompounds 7, 9, and 11; and tetracyclic compounds 5, 6, and 16 utilizing 5-isothiocyanato-3-methyl-thiophene-2,4-dicarboxylic acid diethyl ester 2 are reported. The structures of these compounds were confirmed by microanalyses and IR, 1H NMR, and mass spectroscopy. Preliminary biological studies of some of the synthesized compounds showed promising radioprotective and anticancer activities. |
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| Keywords: | Anticancer agents new thiophene and thieno[2 3-d]pyrimidine derivatives radioprotective |
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