New NH-substituted 1,4-naphtho- and 1,4-benzo- quinones: Synthesis,characterization and potential antiproliferative effect against MDA-MB-231 cells |
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Authors: | Aysecik Kacmaz Zuhal Hamurcu |
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Institution: | 1. Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Istanbul, Turkey;2. kacmaz@istanbul.edu.tr;4. Department of Medical Biology, Faculty of Medicine, Erciyes University, Kayseri, Turkey |
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Abstract: | AbstractEleven new alkyl and aryl amino quinones were synthesized from quinones (2,3-dibromo-1,4-naphthoquinone 1, 2-bromo-1,4-naphthoquinone 2, p-benzoquinone 3 or 2,6-dichloro-1,4-benzoquinone 8) with primary amines. The structures of all compounds were characterized by spectroscopic technics and elemental analysis. The structure of 2-((6,6-Dimethylbicyclo3.1.1]heptan-2-yl)methylamino)-3-bromonaphthalene-1,4-dione (5a) was established by single crystal diffraction. 2-(2-(Ethylthio)ethylamino)naphthalene-1,4-dione (6b) was found to have noteworthy antiproliferative effect against MDA-MB-231 cells. |
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Keywords: | 1 4-Naphthoquinone p-Benzoquinone X-Ray structure determination MDA-MB-231 cells |
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