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Plakevulin A, a new oxylipin inhibiting DNA polymerases α and γ from sponge Plakortis species |
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| Authors: | Masashi TsudaTadashi Endo Marinela PerpelescuShonen Yoshida Kenji WatanabeJane Fromont Yuzuru MikamiJun'ichi Kobayashi |
| Institution: | a Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-ku, Sapporo 060-0812, Japan b Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya 466-8550, Japan c Faculty of Agriculture, Hokkaido University, Sapporo 060-8589, Japan d Western Australian Museum, Perth, WA 6000, Australia e Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba 260-0856, Japan |
| Abstract: | A new cytotoxic oxylipin, plakevulin A (1), possessing a cyclopentene ring and a levulinyl ester has been isolated from an Okinawan marine sponge Plakortis sp. The structure was elucidated on the basis of spectroscopic data, and the absolute configurations at three chiral centers were assigned by spectroscopic data of the reductive product of 1 and a modified Mosher's method. Plakevulin A (1) exhibited inhibitory activity against DNA polymerases α and γ. |
| Keywords: | plakevulin A DNA polymerase Mosher's method |
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