Expeditious synthesis of 5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidin-2-ones and 3,4,6,7,8,9-hexahydro-pyrimido[1,2-a]pyrimidin-2-ones |
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Authors: | Richa Pathak |
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Institution: | Medicinal and Process Chemistry Division, Central Drug Research Institute, PO Box 173, Lucknow 226001, India |
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Abstract: | A convenient synthesis of new 5,6,7,8-tetrahydro-imidazo1,2-a]pyrimidin-2-ones and 3,4,6,7,8,9-hexahydro-pyrimido1,2-a]pyrimidin-2-ones from the Baylis-Hillman adducts of acrylonitrile and their derivatives is described. A common strategy employed to achieve the syntheses of title compounds involved generation of diamines from different Baylis-Hillman derivatives followed by treatment with cyanogen bromide at reflux temperature to trigger a double intramolecular cyclization. |
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Keywords: | Baylis-Hillman 5 6 7 8-Tetrahydro-imidazo[1 2-a]pyrimidin-2-ones 3 4 6 7 8 9-Hexahydro-pyrimido[1 2-a]pyrimidin-2-ones Cyanogen bromide |
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