Synthesis and characterization of quinoline derivatives via the Friedländer reaction |
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| Authors: | Dingqiao Yang Kailing Jiang Jingning Li Feng Xu |
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| Institution: | School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China |
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| Abstract: | A rapid and efficient method for the synthesis of various poly-substituted quinolines has been developed via the Friedländer condensation of 2-aminoarylaldehyde with a carbonyl compound containing a reactive α-methylene group in the presence of sodium ethoxide (10 mol %). The new tetrahydroacridine derivatives and 11H-indeno1,2-b]quinolines were synthesized in high yield with sodium ethoxide as a catalyst via the Friedländer reaction. The conditions of reaction were discussed and the possible reaction mechanism was proposed. |
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| Keywords: | The Friedlä nder condensation reaction 2-Amino-3 6-dimethoxy-benzaldehyde 11H-Indeno[1 2-b]quinoline Tetrahydroacridine derivatives |
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