New synthesis of two optically active steroid CD ring synthons by microbial asymmetric reduction |
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| Authors: | Wei-Min Dai Wei-Shan Zhou |
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| Institution: | Shanghai Institute of Organic Chemistry, Academia Sinica 345 Lingling Lu, ShanghaiChina |
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| Abstract: | Two optically active steroid CD ring synthons 4 and 19 were synthesized from 11 obtained by the microbial asymmetric reduction of a pro-chiral trione 10 which could be efficiently prepared by the reaction of a new annelating reagent 9 with 2-ethyl-cyclopentane-1, 3-dione. |
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