首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Hydrochlorofluoromethylation of unactivated alkenes with chlorofluoroacetic acid
Institution:1. Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, OX1 3TA, Oxford, UK;2. Discovery Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75A, 45007, Toledo, Spain;3. Discovery Sciences Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340, Beerse, Belgium;1. School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu, 212013, China;2. Hainan Provincial Key Laboratory of Fine Chemistry, Hainan University, Haikou, Hainan 570228, China;1. Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, United States;2. Syngenta, 410 Swing Road, Greensboro, NC 27409, United States;1. School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai, China;2. Shanghai Engineering Research Center of Pharmaceutical Progress, Shanghai, China;3. Shanghai Engineering Research Center of Green Fluoropharmaceutical Technology, Shanghai, China
Abstract:An operationally simple method enabling hydrochlorofluoromethylation of unactivated alkenes under visible light activation is reported. The procedure has various benefits. It uses commercially available and inexpensive chlorofluoroacetic acid and phenyliodine(III) diacetate for the generation of the required chlorofluoromethyl radical, it converts feedstock olefins into attractive 1-chloro-1-fluoroalkanes, and it tolerates a broad variety of functional groups. The chlorofluoromethyl radical has a reactivity profile towards alkenes similar to the nucleophilic difluoromethyl radical.
Keywords:Fluorine  Chlorofluoromethyl radical  Hypervalent iodine  Photochemistry
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号