SiO2-NHC-Cu(I): an efficient and reusable catalyst for [3+2] cycloaddition of organic azides and terminal alkynes under solvent-free reaction conditions at room temperature |
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| Authors: | Pinhua Li Yicheng Zhang |
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| Institution: | a Department of Chemistry, Huaibei Coal Teachers College, Huaibei, Anhui 235000, PR China
b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, PR China |
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| Abstract: | A novel SiO2-NHC-Cu(I) 3b was developed and used as a highly efficient catalyst for 3+2] cycloaddition of organic azides and terminal alkynes. In the presence of SiO2-NHC-Cu(I) 3b (1 mol %), the reactions of terminal alkynes with organic azides underwent smoothly to generate the corresponding regiospecific 1,4-disubstituted 1,2,3-triazoles in excellent yields under solvent-free reaction conditions at room temperature. Furthermore, catalyst 3b was quantitatively recovered from the reaction mixture by a simple filtration and reused for 10 cycles without loss of its activity. |
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| Keywords: | SiO2-NHC-Cu(I) [3+2] Cycloaddition Recyclable Organic azides Alkynes Solvent-free |
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