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Pd/C-catalyzed alkynylation of β-chloroacroleins |
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| Authors: | Rabin Bera Nalivela Kumara Swamy G Dhananjaya J Moses Babu P Rajender Kumar K Mukkanti Manojit Pal |
| Institution: | aCustom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Bollaram Road, Miyapur, Hyderabad 500049, Andhra Pradesh, India bDiscovery Research, Dr. Reddy's Laboratories Ltd., Bollaram Road, Miyapur, Hyderabad 500049, Andhra Pradesh, India cChemistry Division, Institute of Science and Technology, JNT University, Kukatpally, Hyderabad 500072, Andhra Pradesh, India |
| Abstract: | The first Pd/C-mediated Sonogashira coupling of β-chloroacroleins with terminal alkynes is described here. Pd/C–CuI–PPh3 was found to be an efficient catalyst system for this coupling reaction. Using this economic and general process a variety of 4-alkynyl-2H-chromene-3-carbaldehydes and 5-alkynyl-2,3-dihydro benzob]oxepine-4-carbaldehydes were prepared in good yields. |
| Keywords: | β-Chloroacroleins Terminal alkynes Palladium catalyst |
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