Enantioselective synthesis of preclavulone A and its methyl ester |
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| Authors: | Alessio Porta |
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| Institution: | Department of Organic Chemistry, University of Pavia, Viale Taramelli, 10, 27100 Pavia, Italy |
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| Abstract: | A highly enantioselective synthesis of the (8S,12S)-enantiomer of preclavulone A and its methyl ester is described featuring the Julia protocol for installing the (Z)-double bond in the lower chain. This procedure is suitable for the preparation of labeled preclavulone analogues for biosynthetic studies on marine clavulones. |
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| Keywords: | Preclavulone A Marine clavulones Enantioselective synthesis Julia olefination |
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