N-Hydroxypyridone alkaloids,chromone derivatives,and tetrahydroxanthones from the scale-insect pathogenic fungus Orbiocrella sp. BCC 33248 |
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| Authors: | Masahiko Isaka Rachada HaritakunSumalee Supothina Wilunda ChoowongSuchada Mongkolsamrit |
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| Institution: | National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand |
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| Abstract: | Six new compounds, an N-hydroxypyridone glucoside, orbiocrellin A (1), its aglycone orbiocrellin B (2), chromone glucosides 3 and 4, a dihydrochromone 5a/5b, and a chromone 6, were isolated from the scale-insect pathogenic fungus Orbiocrella sp. BCC 33248. Orbiocrellin A (1) exhibited antimalarial activity against Plasmodium falciparum K1 (IC50 3.1 μg/mL) while it was non-cytotoxic. In contrast, orbiocrellin B (2) showed both antimalarial (IC50 2.1 μg/mL) and cytotoxic (NCI-H187 cells, IC50 0.70 μg/mL) activities. |
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| Keywords: | Orbiocrella Invertebrate pathogenic fungi Antimalarial activity Cytotoxicity |
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