Chiral imines prepared from 1-(2-aminoalkyl)aziridines as novel chiral shifts reagents for efficient recognition of acids |
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Authors: | Adam M Pieczonka Stanisław Leśniak Michał Rachwalski |
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Institution: | Department of Organic and Applied Chemistry, University of ?ód?, Tamka 12, 91-403, ?ód?, Poland |
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Abstract: | Optically pure, chiral imines synthesized from the corresponding aldehydes and 1-(2-aminoalkyl)aziridines in good chemical yields, have been assessed as an NMR chiral shift reagents for effective discrimination of the signals of some acids (mandelic acid and its derivatives and N-protected amino acid). The title compounds have proven to be very useful for the determination of enantiomeric purity and absolute configuration of the aforementioned acid derivatives. |
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Keywords: | Asymmetric synthesis Aziridines Chiral solvating agents Chiral shift reagents |
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