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Studies on the synthesis of the lasubine alkaloids |
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| Authors: | Nur Filza bte Mohamed Aslam Oliver Simon Roderick W Bates |
| Institution: | 1. Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, Singapore 138670, Singapore;2. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore |
| Abstract: | Formal syntheses of lasubine II and subcosine II have been completed by the synthesis of epi-lasubine II. The synthesis involves diastereoselective allylation of a methoxy isoxazolidine and a tandem hydrogenation process leading stereoselectively to a trisubstituted piperidine. |
| Keywords: | Alkaloid Indolizidine Isoxazolidine Tandem Allylation |
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