Facile preparation of 3-substituted 2-quinazolinones via electrogenerated base |
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Authors: | Najwa Sbei Belen Batanero Fructuoso Barba Beya Haouas Mohamed Lamine Benkhoud Isidoro Barba |
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Institution: | 1. Department of Organic Chemistry, University of Alcalá, 28871 Alcalá de Henares, Madrid, Spain;2. Instituto de Investigación Química “Andrés M. del Río” (IQAR), University of Alcalá, 28871 Alcalá de Henares, Madrid, Spain;3. Laboratoire de Chimie Analytique et d''Electrochimie, Faculté des Sciences, Université Tunis El Manar, 2092 El-Manar, Tunis, Tunisia |
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Abstract: | A new series of 3,4-disubstituted quinazolin-2-ones, with potential T-type calcium channel antagonist activity, and new 4-methylene-quinazolin-2-ones, promising catalysts as N-heterocyclic olefins, have been prepared in good yield by a simple reaction between 2-aminobenzophenone, or 2-aminoacetophenone, and cyanomethyl anion electrogenerated by acetonitrile reduction at a graphite electrode, followed by the addition of different organic isocyanates and subsequent heterocyclization. |
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Keywords: | Quinazolin-2-ones Magnesium sacrificial anode Electrogenerated cyanomethyl anion Organic isocyanates |
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