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Dichotellides A-E, five new iodine-containing briarane type diterpenoids from Dichotella gemmacea |
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| Authors: | Jian-Fan Sun Hui Huang Xing-Yun ChaiXian-Wen Yang Li MengCai-Guo Huang Xue-Feng ZhouBin Yang Jing HuXian-Qiang Chen Hui LeiLishu Wang Yonghong Liu |
| Institution: | a Key Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China b Graduate School of Chinese Academy of Sciences, Beijing 100049, China c National Experiment Station of Tropical Marine Biology, Sanya 572000, China d Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai 200433, China e Jilin Provincial Academy of Chinese Medicine Sciences, Changchun 130021, China |
| Abstract: | Five new briarane type diterpenoids, dichotellides A−E (1−5), were isolated from the South China Sea gorgonian Dichotella gemmacea together with four known analogues (6−9). Compounds 1−5 represent the first examples of iodine-containing briarane type diterpenoids from nature. The structures of these diterpenoids were elucidated by spectroscopic analysis, including 1D, 2D-NMR, and HRESIMS, and the absolute configuration of 1 was further confirmed by single crystal X-ray diffraction analysis. All the isolates were evaluated for cytotoxicity activity against four human tumor cell lines, and only 3 exhibited marginal activity against SW1990 (human pancreatic cancer). |
| Keywords: | Dichotella gemmacea Gorgonian Iodine-containing briarane type diterpenoid Dichotellides X-ray diffraction Cytotoxicity |
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