Enantioselective cyanocarbonation of ketones with chiral base |
| |
Authors: | Shi-Kai Tian |
| |
Institution: | Department of Chemistry, Brandeis University, Waltham, MA 02454-9110, USA |
| |
Abstract: | A highly enantioselective cyanocarbonation of dialkyl ketones catalyzed by commercially available and easily recyclable cinchona alkaloid derivatives has been developed. The reaction provides a useful approach for the enantioselective construction of tetrasubstituted carbon stereocenters. Mechanistic studies have been carried out to shed light on the origin of the catalytic activity of the cinchona alkaloid and the asymmetric induction step. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|