Preparation of 4(3H)-quinazolinones from aryldiazonium salt,nitriles and 2-aminobenzoate via a cascade annulation |
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| Authors: | Mani Ramanathan Ming-Tsung Hsu Shiuh-Tzung Liu |
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| Institution: | Department of Chemistry, National Taiwan University, Taipei 106, Taiwan |
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| Abstract: | One-pot synthesis of 3-aryl-4(3H)-quinazolinones has been realized through a cascade annulation. Reaction of aryldiazonium salt with a nitrile provides in situ generation of a reactive nitrilium ion, which is attacked by the amino group of 2-aminobenzoate followed by cyclization to deliver the desired product. This strategy offers a convenient and easy access to a wide range of functionalized quinazolinone. |
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| Keywords: | Quinazolinone Diazonium Nitrilium Nitrile Annulation |
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