|
|||||
|
|
Metal-free synthesis of 2-difluoromethylated quinolines via DBU-promoted cascade michael addition / cyclization of methyl 4,4-difluorobut-2-ynoate with 2-aminobenzonitriles |
|
| Authors: | Zhenhua Fan Shanxue Yang Xin Peng Cheng Zhang Jing Han Jie Chen Hongmei Deng Min Shao Hui Zhang Weiguo Cao |
| Institution: | 1. Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai, 200444, PR China;2. Qianweichang College, Shanghai University, Shanghai, 200444, PR China;3. Laboratory for Microstructures, Instrumental Analysis and Research Center of Shanghai University, Shanghai, 200444, PR China;4. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, PR China;5. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, PR China |
| Abstract: | A facile synthesis of 2-difluoromethylated quinolines via DBU-promoted cascade Michael addition/cyclization between functionalized 2-aminobenzonitriles and methyl 4,4-difluorobut-2-ynoate has been developed. Various highly functionalized quinolines were assembled in moderate to good yields under mild metal-free reaction conditions. |
| Keywords: | Quinoline Difluoromethylation Heterocycle synthesis |
| 本文献已被 ScienceDirect 等数据库收录！ | |