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Briaexcavatins C-F, four new briarane-related diterpenoids from the Formosan octocoral Briareum excavatum (Briareidae) |
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| Authors: | Ping-Jyun Sung Yu-Pei Chen Tsong-Long Hwang Lee-Shing Fang Yang-Chang Wu Jyh-Horng Sheu |
| Institution: | a National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan, ROC b Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan, ROC c Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, ROC d Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan, ROC e Faculty of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC f Institute of Marine Biodiversity and Evolution, National Dong Hwa University, Pingtung 944, Taiwan, ROC g Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC |
| Abstract: | Four new briarane-related diterpenoids, designated as briaexcavatins C-F (1-4), were isolated from the Formosan octocoral Briareum excavatum, collected off southern Taiwan coast. The structures of these new metabolites were elucidated by the interpretation of spectroscopic and chemical methods. The configuration of 1 was further supported by molecular mechanics calculations. Briarane 1 has been shown to exhibit mild cytotoxicity toward MDA-MB-231 human breast tumor cells and briarane 3 was found to show activity to inhibit neutrophil elastase release in humans. |
| Keywords: | Briarane Briaexcavatin Briareum excavatum Octocoral Cytotoxicity Human neutrophil elastase |
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