PPh3/I2/HCOOH: An efficient CO source for the synthesis of phthalimides |
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| Authors: | Yingying Wang Yang Zhou Min Lei Jinjun Hou Qinghao Jin Dean Guo Wanying Wu |
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| Institution: | 1. Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China |
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| Abstract: | A straightforward and general method has been developed for the synthesis of phthalimide derivatives from 2-iodobenzamides and PPh3/I2/HCOOH in the presence of a catalytic amount of Pd(OAc)2. The reaction results demonstrate that PPh3/I2/HCOOH is a facile, efficient and safe CO source. The whole process is carried out in toluene at 80?°C and furnishes the desired products in good to excellent yields. |
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| Keywords: | Phthalimide 2-Iodobenzamide CO source |
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