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Cu-catalyzed regio- and stereoselective sulfonylation of multi-substituted allenes |
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| Authors: | Shigeru Arai Koki Matsumoto Atsushi Nishida |
| Institution: | 1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan;2. Molecular Chirality Research Center, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba, 263-8522, Japan |
| Abstract: | Regio- and stereoselective sulfonylation of allenes under Cu catalysis is described. Allenyl sp carbons exclusively react with TsCN to give the corresponding alkenyl sulfones. The reaction is initiated by addition of tosyl radical to form benzyl radical intermediates, which determines the reaction pathway. The structure of the products is highly dependent on the substituents on allenes. |
| Keywords: | Allenes Cu Catalysis Regioselective Stereoselective |
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