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A novel and efficient approach to highly substituted indolizines via 5-endo-trig iodocyclization |
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| Authors: | Ikyon Kim Hye Kyoung Won Jihyun Choi Ge Hyeong Lee |
| Institution: | aCenter for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea |
| Abstract: | A new approach to indolizines has been developed using a 5-endo-trig iodocyclization of allylic esters followed by isomerization and dehydroiodination facilitated by triethylamine at rt. This mild procedure enabled us to synthesize a number of highly substituted indolizines in good yields. |
| Keywords: | Indolizine Iodine 5-endo-trig Iodocyclization Environmentally benign |
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