Synthesis of C2-functionalized pyrimidines from 3,4-dihydropyrimidin-2(1H)-ones by the Mitsunobu coupling reaction |
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| Authors: | Xi-Cun Wang Guo-Jun Yang Xiao-Dong Jia Zhang Zhang Yu-Xia Da Zheng-Jun Quan |
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| Institution: | a Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education, Gansu 730070, PR China
b Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Anning East Road 967#, Lanzhou, Gansu 730070, PR China |
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| Abstract: | The Biginelli 3,4-dihydropyrimidin-2(1H)-one was converted to various C2-multifunctionalized pyrimidines via the dehydrogenation and Mitsunobu reaction using amines, alcohols, phenols and carboxylic acids as nucleophiles. A possible mechanism was also proposed to rationalize the formation of products. |
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| Keywords: | C2-Functionalized pyrimidines Mitsunobu coupling reaction 3 4-Dihydropyrimidin-2(1H)-ones Dehydrogenation Nucleophiles |
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