Synthetic studies towards zetekitoxin AB: preparation of 4,5-epi-11-hydroxy-saxitoxinol |
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| Authors: | Aaron D Pearson Robert M Williams |
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| Institution: | Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA |
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| Abstract: | A concise synthesis of 4,5-epi-11-hydroxy-saxitoxinol utilizing d-ribose to direct an asymmetric Mannich reaction. This approach allows many modes of reactivity, which can be used to access various analogs of saxitoxin. |
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| Keywords: | Saxitoxin Zetekitoxin AB Mannich reaction Sodium channel Diamino acid |
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