|
|||||
|
|
Solid support synthesis of 14- and 17-membered macrocycles via the SNAr methodology |
|
| Authors: | Alexander S Kiselyov Leon Smith II Paul Tempest |
| Institution: | Small Molecule Drug Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1789, U.S.A. |
| Abstract: | Efficient assembly of 14-membered macrocycles utilizing the SNAr of fluorine in 3-fluoro-4-nitrobenzoic acid with the OH of 3-hydroxytyrosine on solid support is reported. The flexibility of this synthesis, as well as the excellent purity (>90%) of the final products are the distinctive characteristic of the resultant library. |
| Keywords: | macrocycles supported reagents/reactions solid-phase synthesis |
| 本文献已被 ScienceDirect 等数据库收录！ | |