Bioactive meroditerpenes and indole alkaloids from the soil fungus Neosartorya fischeri (KUFC 6344), and the marine-derived fungi Neosartorya laciniosa (KUFC 7896) and Neosartorya tsunodae (KUFC 9213) |
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| Authors: | Amnat Eamvijarn Nelson M Gomes Tida Dethoup Jamrearn Buaruang Leka Manoch Artur Silva Madalena Pedro Ioulia Marini Vasilios Roussis Anake Kijjoa |
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| Institution: | 1. ICBAS – Instituto de Ciências Biomédicas de Abel Salazar and CIIMAR, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal;2. Department of Plant Pathology, Faculty of Agriculture, Kasetsart University, Bangkok, Thailand;3. Division of Environmental Science, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand;4. Departamento de Química, Universidade de Aveiro, 4810-1933 Aveiro, Portugal;5. CEQUIMED – Centro de Química Medicinal da Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal;6. Grupo de Biologia Molecular e Celular (GBMC), Centro de Investigação em Ciências da Saúde (CICS), Instituto Superior de Ciências da Saúde do Norte, CESPU, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal;g Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece |
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| Abstract: | Two new metabolites including a new aszonalenin analogue (1c) and a new meroditerpene (3) were isolated, together with aszonalenin (1a), acetylaszonalenin (1b), 13-oxofumitremorgin B (2), aszonapyrone A (4b) and helvolic acid, from the culture of the soil fungus Neosartorya fischeri (KUFC 6344). While the ethyl acetate extract of the culture of the diseased coral-derived fungus Neosartorya laciniosa (KUFC 7896) furnished aszonapyrone B (4a), aszonapyrone A (4b), tryptoquivaline L and 3′-(4-oxoquinazolin-3-yl) spiro1H-indole-3,5′-oxolane]-2,2′-dione, the ethyl acetate extract of the culture of the marine sponge-associated fungus Neosartorya tsunodae (KUFC 9213) yielded a new analogue of chevalone C (5) and helvolic acid. The structures of the new compounds were established based on 1D and 2D NMR spectral analysis as well as HR-ESIMS. Compounds 1a–c, 2, 3, 4a, 4b and 5 were evaluated for their in vitro growth inhibitory activity on the MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A375-C5 (melanoma) cell lines by the protein binding dye SRB method. |
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| Keywords: | Neosartorya fischeri (KUFC 6344) Neosartorya laciniosa (KUFC 7896) Neosartorya tsunodae (KUFC 9213) Meroditerpenes Sartorypyrones Aszonalenin |
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