Lipophilic phthalocyanines for their potential interest in photodynamic therapy: synthesis and photo-physical properties |
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| Authors: | Albert Moussaron Philippe Arnoux Régis Vanderesse Estelle Sibille Patrick Chaimbault Céline Frochot |
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| Institution: | 1. Université de Lorraine, Laboratoire Réactions et Génie des Procédés (LRGP), UMR 7274, Nancy F-54000, France;2. CNRS, LRGP, UMR 7274, Nancy F-54000, France;3. Université de Lorraine, Laboratoire de Chimie Physique Macromoléculaire (LCPM), FRE CNRS 3564, Nancy F-54000, France;4. CNRS, LCPM, FRE CNRS 3564, Nancy F-54000, France;5. GDR CNRS 3049 “Médicaments Photoactivables-Photochimiothérapie (PHOTOMED)”, France;6. Laboratoire de Chimie et Physique Approche Multiéchelle des Milieux Complexes LCP-A2MC (EA 4632) ICPM, Université de Lorraine, 1 Boulevard Arago, 57078 Metz Cedex 3, France |
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| Abstract: | Several phthalocyanines with different peripheral substituents were prepared and characterized by MALDI-TOF, 1H NMR, UV–vis, fluorescence, and singlet oxygen quantum yields and retention time in HPLC normal phase. Zinc was used as a central metal ion to increase the photodynamic therapy efficiency. Phthalonitrile or 4-nitro phthalonitriles were used as starting materials. The influence of lipophilicity on the photophysical and photochemical properties was evaluated. |
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| Keywords: | Synthesis Phthalocyanines Photodynamic therapy Lipophylic Bathochromic |
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