Thermodynamics of some long-chain biradicals studied by EPR spectroscopy |
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Authors: | S Sankarapandi J M Rifkind and P T Manoharan |
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Institution: | (1) Department of Chemistry, Indian Institute of Technology, 600 036 Madras, India;(2) Laboratory of Cellular and Molecular Biology, Gerontology Research Center, NIA/NIH, 21224 Baltimore, Maryland, USA |
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Abstract: | Four biradicals of differing chain lengths have been prepared by spin-labelling the sulphhydryl groups of dithiothreitol.
Temperature-dependent EPR spectra of these biradicals indicate that the dynamics of biradicals is associated with both fast
and slow exchanges of conformations. The three-conformational model incorporating cage configuration is found to be more appropriate.
Certain thermodynamic parameters of conformationalchanges have been calculated from the experimental EPR parameters, obtained
by the use of simulation procedures developed recently. |
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Keywords: | Biradicals EPR spectroscopy simulation thermodynamic parameters conformational changes fast and slow exchanges |
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