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多氯代二苯并呋喃在不同色谱柱上的气相色谱保留行为——定量结构-色谱保留关系(QSRR)的研究
引用本文:林治华,刘树深,李志良.多氯代二苯并呋喃在不同色谱柱上的气相色谱保留行为——定量结构-色谱保留关系(QSRR)的研究[J].色谱,2001,19(2):116-123.
作者姓名:林治华  刘树深  李志良
作者单位:1. 重庆大学环境与化学化工学院;渝州大学化学系
2. 重庆大学生物工程学院,
3. 重庆大学环境与化学化工学院;重庆大学生物工程学院
基金项目:国家教育部“春晖计划”项目基金、霍英东基金资助课题、重庆市教委99专项基金资助
摘    要: 以一种拟原子的方式处理多氯代二苯并呋喃 (PCDFs)异构体中的苯环 ,将PCDFs异构体中的原子或基团分为 3类 ,即 :氯原子 (Cl) (记为“1”) ,氧原子 (O) (记为“2”)及拟原子 (B) (记为“3”)。在烷烃分子距边矢量的基础上 ,提出一种以基团为基准的分子距离边数矢量 (μ矢量 ) ,借助多元线性回归方法分别建立了多氯代二苯并呋喃在不同色谱柱上的色谱保留指数与表征其结构的 μ矢量间的定量结构 色谱保留关系 (QSRR)相关模型。各样本总体所建模型的相关系数均在 0 98以上。

关 键 词:定量结构-色谱保留关系(QSRR)  分子距边矢量  多氯代二苯并呋喃  色谱保留行为  分子建模
文章编号:1000-8713(2001)02-0116-08
修稿时间:2000年7月15日

Quantitative Structure-Retention Relationship (QSRR) Studies of Polychlorinated Dibenzofurans (PCDFs) on Diverse Gas Chromatographic Stationary Phases on a Set of Novel Molecular Distance Edge Vector
LIN Zhi hua ,LIU Shu shen ,LI Zhi liang.Quantitative Structure-Retention Relationship (QSRR) Studies of Polychlorinated Dibenzofurans (PCDFs) on Diverse Gas Chromatographic Stationary Phases on a Set of Novel Molecular Distance Edge Vector[J].Chinese Journal of Chromatography,2001,19(2):116-123.
Authors:LIN Zhi hua    LIU Shu shen  LI Zhi liang
Institution:College of Environment and Chemistry and Chemical Engineering, Chongqing University, Department of Chemistry, Yuzhou University, Chongqing, China.
Abstract:By taking phenyl as a pseudo atom, there are three types of atom in the polychlorinated dibenzofuran (PCDF) molecule, being chlorine atom, oxygen atom and pseudo atom. The chemical structure of PCDF congeners is depicted by a novel molecular distance-edge vector(VMDE, mu in short), developed in our laboratory, which consists of the modified VMDE parameters based on the identical group as a pseudo atom instead of a traditional atom. Furthermore quantitative structure-retention relationships (QSRR) between the new mu vector and gas chromatographic (GC) retention behavior of PCDFs are generated by multiple linear regression method for various stationary phases. Four models, each of which is constructed by using all sample sets, with high correlation coefficient, r > 0.98, are developed for three columns (DB-5, SE-54, OV-101). In order to test the equation stability and prediction ability of each model, it is essential to perform a cross validation (CV) procedure. Satisfactory CV results have been obtained by using one external predicted sample every time with high correlation coefficients, r > 0.97. These results show that the new mu vector has high structural selectivity and good property relativity, and it is easy to calculate the mu vector. And the QSRR models have high relative coefficients, good stability and good predictability.
Keywords:quantitative structure  retention relationship (QSRR)  molecular distance  edge vector  polychlorinated dibenzofuran  retention behavior  molecular modeling
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