有机锗化合物的离子色谱法分析研究

研究了３种有机锗化合物：β－羧乙基锗倍半氧化物、β－（α－甲基）羧乙基锗倍半氧化物、二－（β－羧乙基）锗氢氧化物的离子色谱法分离和测定条件。以四硼酸钠溶液为淋洗液，硫酸溶液为再生液，梯度淋洗。３种化合物均达到基线分离，检出限分别为０．０３８，０．０３５和０．０２５ｍｇ／Ｌ（以锗计）。方法已用于保健口服液的测定，加标回收率为９５％～１０１％，其结果与氢化物发生－原子荧光光谱法的结果吻合。

Study on the Analysis of Organogermanium Compounds by Ion Chromatography

A new high performance ion exchange chromatographic method for separation and determination of three organogermanium compounds beta-carboxyethylgermanium sesquioxide (I), beta-(alpha-methyl) carboxyethylgermanium sesquioxide (II) and di-(beta-carboxyethyl) germanium hydroxide (III) has been developed. A Dionex DX-300 Ion Chromatograph equipped with a Dionex PED-II pulsed electrochemical detector (conductivity mode), a Dionex AMMS-1 anion micromembrane suppressor, and a Dionex ACI advanced computer interface coupled with AI-450 chromatographic software was employed. The separation was achieved by using a Dionex IonPac AS4A-SC column as analytical column, sodium tetraborate solution as eluent, and sulfuric acid solution as regenerant. For reducing run time, a gradient program was chosen. The detection limits (S/N = 3, expressed as germanium) for the three compounds were 0.038mg/L (I), 0.035mg/L (II) and 0.025mg/L (III), respectively. The method has been applied to the analysis of two tonic oral drinks, and the average recoveries for the three compounds ranged from 95%-101%. The results obtained were in agreement with those of hydride generation atomic fluorescence spectrometry (HG-AFS).