| 高效液相色谱溶剂系统四面体优化法 |
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| 引用本文： | 吴文,班允东,邸欣,潘萌,孙毓庆.高效液相色谱溶剂系统四面体优化法[J].色谱,1994,12(5):345-347. |
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| 作者姓名： | 吴文 班允东 邸欣 潘萌 孙毓庆 |
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| 作者单位： | 沈阳药学院 |
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| 摘 要： | 改进了Ｇｌａｊｃｈ的三角形法，建立了适合于高效液相色谱（ＨＰＬＣ）的四面体优化法。将７个溶剂系统的实验结果输入计算机，由计算机模拟２３１个溶剂系统的色谱行为，优选出最佳溶剂系统。将此法用于１２种磺胺药物的分离，得到了满意的结果。
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| 关 键 词： | 高效液相色谱 磺胺类药物. 流动相的优化 四面体优化法 |
The Tetrahedron Method of Optimizing Solvent System in High Performance Liquid Chromatography |
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| Wu Wen,Ban Yundong,Di Xin,Pan Meng and Sun Yuqing.The Tetrahedron Method of Optimizing Solvent System in High Performance Liquid Chromatography[J].Chinese Journal of Chromatography,1994,12(5):345-347. |
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| Authors: | Wu Wen Ban Yundong Di Xin Pan Meng and Sun Yuqing |
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| Abstract: | n this paper we modified the triangle method proposed by Glajch and developed the tetrahedron method.In this method,after the experimental results of 7 solvent systems were input into a micro-computer,the latter simulated the chromatographic behaviour of 231 solvent systems and gave the optimal system. The tetra-hedron method has been successfully applied to the separation of 12 sulfadrugs. |
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| Keywords: | high performance liquid chromatography mobile phase optimization the tetrahedron method sulfa drugs |
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