3种金属有机骨架材料用于开管毛细管电色谱手性固定相分离外消旋体

金属有机骨架(MOFs)材料因具有丰富的拓扑结构、高比表面积、良好的稳定性、持久的孔结构以及可修饰的孔道表面等特点,在对映选择性催化和手性分离方面备受关注。该文通过水热法合成了3种具有手性的MOFs晶体,分别为Co2(D-cam)2(TMDPy)(简称为MOF 1)、Cd(D-cam)(tmdpy)]·2H2O(简称为MOF 2)和Co0.5Zn0.5(L-Tyr)]n(L-tyrCo/Zn)(简称为MOF 3),并把它们用作固定相分别制成MOFs手性柱进行开管毛细管电色谱(OT-CEC)研究。在磷酸二氢钠-乙腈的流动相体系下,考察了3根MOFs手性柱对手性化合物的拆分性能。实验结果表明,这3种MOFs手性毛细管柱对部分外消旋体具有较好的拆分效果。目前将手性MOFs作为毛细管电色谱手性分离的研究正处在起步阶段并且具有良好的应用前景。

Three chiral metal organic frameworks used as stationary phases for the separation of racemates by open tubular capillary electrochromatography

Metal organic frameworks (MOFs) have attracted a tremendous attention in enantioselective catalysis and separation due to their unusual properties such as rich topologies, high surface area, good stability, permanent micropocity, availability of outer-surface modification and so on. In this study, three chiral MOFs, Co₂(D-cam)₂(TMDPy) (abbreviated as MOF 1),Cd(D-cam)(tmdpy)]·2H₂O (abbreviated as MOF 2) andCo_0.5Zn_0.5(L-Tyr)]_n(L-tyrCo/Zn) (abbreviated as MOF 3) were synthesized and respectively used as chiral stationary phases in open tubular capillary electrochromatography (OT-CEC). The three MOFs were characterized by powder X-ray diffraction (XRD) and scanning electron microscope (SEM). The three MOFs coated columns were developed using a simple procedure via MOFs post-coated on the sodium silicate layer. The experimental results showed that the three MOFs based chiral columns had better recognition ability toward some racemates. The baseline separation of furoin was achieved on the MOF 1 coated column with high resolution of more than 2.10. The influences of pH, organic modifier content and buffer concentration on the separation were investigated. The results demonstrated that chiral MOFs were promising for enantioseparation in CEC.