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种子溶胀悬浮聚合法制备分子印迹聚合物微球
引用本文:成国祥,张立永,付聪.种子溶胀悬浮聚合法制备分子印迹聚合物微球[J].色谱,2002,20(2):102-107.
作者姓名:成国祥  张立永  付聪
作者单位:天津大学材料科学与工程学院,天津,300072
基金项目:国家自然科学基金资助课题 ( 2 990 6 0 0 8)
摘    要: 以酪氨酸为印迹分子 ,甲基丙烯酸为功能单体 ,三羟甲基丙烷三甲基丙烯酸酯 (TRIM )为交联剂 ,采用种子溶胀悬浮聚合法在水溶液中制备了一系列分子印迹聚合物微球 (MIPMs)。利用扫描电镜 (SEM)对此微球的粒径大小、粒径分布、表面孔与孔径分布等进行了分析研究 ,探讨了影响其形貌的主要因素 ,并将所得微球用作固定相研究了其分子选择吸附性能。研究表明 ,种子溶胀悬浮聚合法能够制得单分散性较好的、表面带有微孔的分子印迹聚合物微球 ,且该微球呈现出较好的特异吸附性能。

关 键 词:种子溶胀悬浮聚合  分子印迹聚合物微球  单分散性
文章编号:1000-8713(2002)02-0102-06
修稿时间:2001年11月16

Molecularly Imprinted Polymeric Microspheres Prepared by Seed Swelling and Suspension Polymerization
CHENG Guo-xiang,ZHANG Li-yong,FU Cong.Molecularly Imprinted Polymeric Microspheres Prepared by Seed Swelling and Suspension Polymerization[J].Chinese Journal of Chromatography,2002,20(2):102-107.
Authors:CHENG Guo-xiang  ZHANG Li-yong  FU Cong
Institution:School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China. gxcheng@tju.edu.cn
Abstract:A series of molecularly imprinted polymeric microspheres(MIPMs) were prepared by seed swelling and suspension polymerization method in aqueous system using tyrosine as printing molecules, methacrylic acid as functional monomers and trimethylolpropane trimethacrylate (TRIM) as cross-linkers. The morphology including the size, size distribution, pore and pore distribution of the polymer beads was analyzed by scanning electron microscope(SEM). The major factors that influence these properties of the beads are discussed. The molecule selecting property of the MIPMs was detected through liquid chromatography. The results showed that uniform-sized spherical MIPMs had been prepared in aqueous system by seed swelling and suspension polymerization method, and its surface was distributed with pores between 1 micron to 10 microns. The average bead size was adjusted from about 50 microns to 400 microns by changing the stirring speed and the amount of seeds used during the preparation. The prepared MIPMs exhibited a considerable tendency to adsorb tyrosine, the printing molecules selectively, and the separation factor was up to 1.82 when phenylalanine was chosen as the competitive molecules.
Keywords:seed swelling and suspension polymerization  molecularly imprinted polymeric microsphere  monodispersity
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