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高效液相色谱法同时检测化妆品中12种直接染料
引用本文:潘城,吴凌,谢勇,许文琪,白洋,黄永辉,胡朝阳.高效液相色谱法同时检测化妆品中12种直接染料[J].色谱,2018,36(9):904-910.
作者姓名:潘城  吴凌  谢勇  许文琪  白洋  黄永辉  胡朝阳
作者单位:福建省产品质量检验研究院, 福建 福州 350002
基金项目:福建省产品质量检验研究院院课题项目(KY201526A).
摘    要:建立了高效液相色谱分离检测化妆品中12种直接染料的方法。采用XB-C18色谱柱分离,以乙腈-0.02mol/L乙酸铵水溶液(pH 9.0)为流动相梯度洗脱,二极管阵列检测器检测。结果表明,12种直接染料在线性范围内具有良好的线性关系,相关系数均0.999;方法的检出限为0.017~1.7μg/g,回收率为85.6%~113.4%,相对标准偏差为1.0%~7.7%;日内和日间精密度分别为0.4%~6.5%和0.2%~7.5%。该法简单快速,灵敏度高,定量准确可靠,适用于化妆品中直接染料的日常检测。

关 键 词:高效液相色谱  直接染料  化妆品
收稿时间:2018-04-12

Simultaneous determination of 12 direct dyes in cosmetics by high performance liquid chromatography
PAN Cheng,WU Ling,XIE Yong,XU Wenqi,BAI Yang,HUANG Yonghui,HU Chaoyang.Simultaneous determination of 12 direct dyes in cosmetics by high performance liquid chromatography[J].Chinese Journal of Chromatography,2018,36(9):904-910.
Authors:PAN Cheng  WU Ling  XIE Yong  XU Wenqi  BAI Yang  HUANG Yonghui  HU Chaoyang
Institution:Fujian Inspection and Research Institute for Product Quality, Fuzhou 350002, China
Abstract:A method was developed for the simultaneous separation and determination of 12 direct dyes in cosmetics by high performance liquid chromatography (HPLC). The analytes were separated on an XB-C18 column with acetonitrile-0.02 mol/L ammonium acetate aqueous solution (pH 9.0) as the mobile phases, and were detected using a diode array detector. The results indicated that the 12 direct dyes had good linearities with correlation coefficients greater than 0.999. The limits of detection were between 0.017 μ g/g and 1.7 μ g/g. The average recoveries ranged from 85.6% to 113.4%, and the relative standard deviations (RSDs) ranged from 1.0% to 7.7%. The intra-and inter-day RSDs were 0.4%-6.5% and 0.2%-7.5%, respectively. The method is simple, rapid, accurate, and is suitable for the determination of direct dyes in cosmetics.
Keywords:high performance liquid chromatography (HPLC)  direct dyes  cosmetics
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