食品中化学性有害物的质谱软电离裂解规律及筛查技术研究进展

食品中化学性有害物是导致食品安全问题的重要原因,质谱是对食品中化学性有害物进行定性定量分析的有效方法。该文按照化合物结构类别,综述了食品中重要化学性有害物的质谱软电离裂解机理,包括农药、兽药、真菌毒素,以及其他化学污染物。对于每类化合物,重点综述化合物质谱裂解产生的特征碎片、中性丢失等,以及这些质谱软电离裂解机理在食品中化学性有害物筛查及发现中的应用。研究化合物的质谱裂解机理可以帮助研究者对化合物进行结构解析和结构确证,为食品中同类结构新型化学性有害物的发掘提供理论依据。

Research progress on the fragmentation mechanisms of mass spectrometry soft ionization and screening of chemical hazardous substances in food

Hazardous chemicals in food are an important cause of food safety problems. Mass spectrometry is an effective tool for the qualitative and quantitative analysis of these substances. In this paper, the fragmentation mechanisms for several chemical hazardous substances, including pesticides, veterinary drugs, mycotoxins, and other chemical pollutants classified by structural analogs, are reviewed. For each class of compounds, we summarize the characteristic fragments and neutral loss generated by cleavage in the mass spectrometry analysis. We also summarize the mechanisms applied to screen and discover new structural analogs in food. This review can help researchers analyze and confirm the structure of compounds and provide a theoretical basis for the discovery of new structural analogs in food.