Synthesis of 1,4‐Diaryl‐piperazine‐2,5‐diones: New Behavior of N,N‐Dimethylformamide Dimethyl Acetal (DMFDMA) |
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| Authors: | Fathi A Abu‐Shanab Ahmed Al‐Harrasi Sayed A S Mousa |
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| Institution: | 1. Faculty of Science, Department of Chemistry , Al‐Azhar University , Assiut, Egypt fathiabushanab@yahoo.com;3. Department of Chemistry , College of Science, Sultan Qaboos University , Al‐Khod, Oman;4. Faculty of Science, Department of Chemistry , Al‐Azhar University , Assiut, Egypt |
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| Abstract: | Reactions of chloroacetamides (5) with N,N‐dimethylformamide dimethyl acetal gave 1,4‐diaryl‐piperazine‐2,5‐diones 11a–e in good yield, rather than 1,5‐diaryl‐3,7‐dimethoxy‐1H,5H‐1,5]diazocine‐2,6‐diones (9a–e). |
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| Keywords: | α‐chloroacetamides 1 4‐diarylpiperazine‐2 5‐diones condensation dimerization N N‐dimethylformamide dimethyl acetal |
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