New Procedure for the Preparation of the Tetrazole Analogue of GABA |
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| Authors: | Yveline Rival Camille G Wermuth |
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| Institution: | Laboratoire de Pharmacochimie de la Communication Cellulaire, ERS 655 du CNRS, Université Louis Pasteur , 74 Route du Rhin, 67401, ILLKIRCH Cedex, France |
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| Abstract: | The hydrochloride of the tetrazolyl bioisostere of the neurotransmitter GABA can be easily prepared by means of three simple steps: a Gabriel-type substitution on 4-bromobutyronitrile with Boc2NH, a tetrazole formation by action of azidotributyltin on the cyano group and a deprotection step using gaseous HCl. |
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| Keywords: | Knoevenagel condensation Proline Alkylidene malonate Arylidene malonate Arylidene cyanoacetate |
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