Three-Component Synthesis of Pyrimidine and Pyrimidinone Derivatives in the Presence of High-Surface-Area MgO,a Highly Effective Heterogeneous Base Catalyst |
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| Authors: | Hassan Sheibani Mohammad Seifi Ayoob Bazgir |
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| Institution: | 1. Department of Chemistry , Shahid Bahonar University of Kerman , Kerman, Iran hsheibani@mail.uk.ac.ir;3. Department of Chemistry , Shahid Bahonar University of Kerman , Kerman, Iran;4. Department of Chemistry , Shahid Beheshti University , Tehran, Iran |
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| Abstract: | Magnesium oxide (MgO) effectively catalyzes the three-component reaction of aldehydes, amidine systems, and malononitrile or ethyl cyanoacetate to form 4-amino-5-pyrimidine carbonitrile and pyrimidinone derivatives, respectively. The salient features of this method include high conversions, short reaction times, cleaner reaction profiles, and the use of inexpensive and readily available catalyst. |
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| Keywords: | Amidines 4-amino-5-pyrimidinecarbonitriles magnesium oxide (MgO) malononitrile three-component reaction |
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