Simple and Efficient Purification Protocol of 9-(Trifluoroacetyl)anthracene from Anthracene |
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| Authors: | Justin R Denton |
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| Institution: | 1. Chemical Research and Process Development, Obiter Research , Champaign , Illinois , USA drjdenton@gmail.com;4. justin.denton@obires.com |
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| Abstract: |  A protocol has been developed to purify 9-(trifluoroacetyl)anthracene from anthracene, the major impurity associated in its synthesis. The protocol utilizes a chemoselective thermal Diels–Alder reaction, employing maleic anhydride as the dienophile. The resulting Diels–Alder adduct can then be removed by extractive workup followed by recrystallization to give 9-(trifluoroacetyl)anthracene with ≥99% chemical purity. |
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| Keywords: | Anthracene 9-anthryltrifluoromethyl ketone Diels–Alder reaction purification strategy 9-(trifluoroacetyl)anthracene |
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