Synthesis of Functionalized Dihydrofurocoumarin Derivatives from 3-Aminoalkyl-4-hydroxycoumarin |
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| Authors: | Pallabi Borah P Seetham Naidu Pulak J Bhuyan |
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| Institution: | 1. Medicinal Chemistry Division, Council of Scientific and Industrial Research, North East Institute of Science and Technology, Jorhat, Assam, Indiapallabibora0123@gmail.com pulak_jyoti@yahoo.com;3. Medicinal Chemistry Division, Council of Scientific and Industrial Research, North East Institute of Science and Technology, Jorhat, Assam, India |
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| Abstract: | Some dihydrofuro-fused coumarin derivatives were synthesized from 3-aminoalkyl-4-hydroxycoumarin via in situ generation of N-ylide. The 3-aminoalkylated 4-hydroxycoumarin derivatives were synthesized from one-pot, three-component reaction of 4-hydroxycoumarin, aryl aldehydes, and secondary amines in ethanol at room temperature. Again, when salicylaldehyde was employed instead of benzaldehyde, interestingly pyranocoumarins were obtained. The reaction protocol can be further explored toward the synthesis of many other heterocyclic fused dihydrofurans. |
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| Keywords: | Aryl aldehyde dihydrofurocoumarins 4-hydroxycoumarin pyrano[3 2-c]-coumarins ylides |
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