Efficient and Facile Three-Component Reaction for the Synthesis of 2-Amine-4,6-diarylpyrimidine Under Solvent-Free Conditions |
| |
| Authors: | Qiya Zhuang HongXia Han Suhui Wang Shuajiang Tu |
| |
| Institution: | 1. College of Chemistry and Chemical Engineering, Xuzhou Normal University , Xuzhou, Jiangsu, China;2. College of Chemistry and Chemical Engineering, Xuzhou Normal University , Xuzhou, Jiangsu, China;3. Key Laboratory of Biotechnology for Medicinal Plant , Xuzhou, Jiangsu, China |
| |
| Abstract: | An efficient and convenient multicomponent reaction for the preparation of 2-amine-4,6-diarylpyrimidine by aromatic aldehydes, aromatic ketones, and guanidine carbonate in the presence of sodium hydroxide under solvent-free conditions is reported. The short reaction time coupled with the simplicity of the reaction procedure make this method one of the most efficient methods for the synthesis of this class of compounds. |
| |
| Keywords: | One-pot reactions pyrimidine solvent-free synthesis |
|
|
